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ID: 1024411•
Inglês•
Interpretação de texto Reading comprehension•
IDCAP•
Prefeitura de Barra do Rocha BA•
Professor Fundamental Nível III Inglês•
2024

Read the excerpt below:

"While the origins of Maya culture remain murky, it's thought to have first emerged between 7000 B.C. and 2000 B.C., when hunter-gatherers abandoned their nomadic habits and created more permanent settlements. Recent analyses suggest that those first settlers came from South America and likely developed their staple food, maize, by 4000 B.C. Maize cultivation dramatically changed the Maya's trajectory, literally fueling the explosion of their society and culture."

Source: https://www.nationalgeographic. com/history/article/who-were-the-maya

Considering the context, the word "murky" can be translated as:

ID: 1024486•
Inglês•
Interpretação de texto Reading comprehension•
IDCAP•
OGMO Paranaguá PR•
Conferente•
2024

O texto seguinte servirá de base para responder à questão.


Manufacturing dips as container outlook slides


The NEOI fell to 48.9 in August from 49.6 in July, indicating deteriorating trade conditions for the third consecutive month. Traded goods slowed in both developed and emerging markets, but India maintained a modest growth in goods exports during August, the last month for which figures are available.

In addition, the global PMI has shown a contraction of manufacturing, signalling a further deterioration in cargo levels in the immediate future.

"China's goods exports fell for the first time in 2024, signalling a broader decline in manufacturing as the year progresses," said global freight forwarder Dimerco.

Headquartered in Taiwan, the Taipei-listed forwarder said that the Federal Reserve's recent interest rate cut may revive global goods trade.

August trading in the US continued to grow amid concerns about a US East Coast strike, and a November election that could see major import tariffs imposed on goods, said Dimerco.

"The early peak season suggests an earlier-than-usual start to the slow season, with expected declines in handling volume from September to December, projected at 2.31m, 2.08m, 1.92m, and 1.89m teu, respectively. If these forecasts hold, total port volume for 2024 could reach 24.98m teu, a 12% increase from 2023," said Alvin Fuh, VP - ocean freight at Dimerco Express Group.

Dynamar analyst Darron Wadey, said: "Approaching 470 vessels bringing around 3.2m teu in capacity are expected to be delivered by the end of 2024."

That massive increase in capacity, and the fact that much of this increase is for larger sized vessels, means that any correction in freight rates should have started up to a year ago, according to Wadey.

"It is only the happenstance of the Red Sea and US East Coast situations that have, artificially, buoyed the markets. When the markets do correct therefore, the falls will only be more dramatic because the inevitable has been delayed whilst the stream of new ships coming online continues," said Wadey.

Drewry Shipping Consultants' analysis shows that blank sailings are expected to increase between 9 September and 7 October with an additional 53 blanked sailings, totalling 90 for the period. Some 67% of these cancelled services were on the Pacific eastbound, while a further 21% on the Asia to Europe trades and 12% on the Atlantic.

Even with these cancelled services, rates are continuing to fall on all the major trades, according to Dimerco.

New entrants are said to be another element to failure of lines to maintain rate levels.

"While the three major alliances are increasing blank sailings, several individual carriers have deployed 11 extra vessels for Europe WB and 14 for TPEB to handle the expected cargo surge before China's Golden Week. However, the anticipated pre-October 1 cargo rush in China did not materialise this year, leaving no backlogs or rollover cargo for these extra loaders to transport," said Dimerco's monthly analysis.

Rebalancing trade can only be achieved through the long-term and steady growth of trade, said Wadey, combined with "a strategic rather than knee-jerk ship ordering policy". These required shifts are generational, he said, "in the short term, political events in the US might lead to an end-2024 rush for cargoes again... but then where does that leave 2025 and beyond?"

Drewry's WCI index fell a further 7% this week, closing at $3,691/feu.

https://www.seatrade-maritime.com/containers/manufacturing-dips-as-container-outlook-slides
Which factor did Darron Wadey highlight as artificially sustaining the market, despite an increase in vessel capacity?

ID: 1024640•
Inglês•
Interpretação de texto Reading comprehension•
IDCAP•
Prefeitura de Vila Rica MT•
Inglês•
2023

Stanford Medicine scientists transform cancer cells into weapons against cancer

March 1, 2023 - By Christopher Vaughan


(1º§) Some cities fight gangs with ex-members whoeducate kids and starve gangs of new recruits. Stanford Medicine researchers have done something similar with cancer — altering cancer cells so that they teach the body's immune system to fight the very cancer the cells came from.


(2º§) "This approach could open up an entirely new therapeutic approach to treating cancer," said Ravi Majeti, MD, PhD, a professor of hematology and the study's senior author. The research was published March 1 in Cancer Discovery. The lead author is Miles Linde, PhD, a former PhD student in immunology who is now at the Fred Hutchinson Cancer Institute in Seattle.


(3º§) Some of the most promising cancer treatments use the patient's own immune system to attack the cancer, often __ taking the brakes off immune responses to cancer or by teaching the immune system to recognize and attack the cancer more vigorously. T cells, part of the immune system that learns to identify and attack new pathogens such as viruses, can be trained to recognize specific cancer antigens, which are proteins that generate an immune response.


(4º§) For instance, in CAR T-cell therapy, T cells are taken from a patient, programmed to recognize a specific cancer antigen, then returned to the patient. But there are many cancer antigens, and physicians sometimes need to guess which ones will be most potent.


(5º§) A better approach would be to train T cells to recognize cancer via processes that more closely mimic the way things naturally occur in the body — like the way a vaccine teaches the immune system to recognize pathogens. T cells learn to recognize pathogens because special antigen presenting cells (APCs) gather pieces of the pathogen and show them to the T cells in a way that tells the T cells, "Here is what the pathogen looks like — go get it."


(6º§) Something similar in cancer would be for APCs to gather up the many antigens that characterize a cancer cell. That way, instead of T cells being programmed to attack one or a few antigens, they are trained to recognize many cancer antigens and are more likely to wage a multipronged attack on the cancer.


(7º§) Now that researchers have become adept at transforming one kind of cell into another, Majeti and his colleagues had a hunch that if they turned cancer cells into a type of APC called macrophages, they would be naturally adept at teaching T cells what to attack.


(8º§) "We hypothesized that maybe cancer cells reprogrammed into macrophage cells could stimulate T cells because those APCs carry all the antigens of the cancer cells they came from," said Majeti, who is also the RZ Cao Professor, assistant director of the Institute for Stem Cell Biology and Regenerative Medicine and director of the Ludwig Center for Cancer Stem Cell Research and Medicine.


(9º§) The study builds on prior research from the Majeti lab showing that cells taken from patients with a type of acute leukemia could be converted into non-leukemic macrophages with many of the properties of APCs.


(10º§) In the current study, the researchers programmed mouse leukemia cells so that some of them could be induced to transform themselves into APCs. When they tested their cancer vaccine strategy on the mouse immune system, the mice successfully cleared the cancer.


(11º§) "When we first saw the data showing clearance of the leukemia in the mice __ working immune systems, we were blown away," Majeti said. "We couldn't believe it worked as well as it did."


(12º§) Other experiments showed that the cells created from cancer cells were indeed acting as antigen-presenting cells that sensitized T cells to the cancer. "What's more, we showed that the immune system remembered what these cells taught them," Majeti said. "When we reintroduced cancer to these mice over 100 days after the initial tumor inoculation, they still had a strong immunological response that protected them."


(13º§) "We wondered, If this works with leukemias, will it also work with solid tumors?" Majeti said. The team tested the same approach using mouse fibrosarcoma, breast cancer, and bone cancer. "The transformation of cancer cells from solid tumors was not as efficient, but we still observed positive results," Majeti said. With all three cancers, the creation of tumor-derived APCs led to significantly improved survival.


(14º§) Lastly, the researchers returned to the original type of acute leukemia. When the human leukemia cell-derived APCs were exposed to human T cells from the same patient, they observed all the signs that would be expected if the APCs were indeed teaching the T cells how to attack the leukemia.


(15º§) "We showed that reprogrammed tumor cells could lead to a durable and systemic attack on the cancer in mice and a similar response with human patient immune cells," Majeti said. "In the future we might be able to take out tumor cells, transform them into APCs and give them back to patients as a therapeutic cancer vaccine."


(16º§) "Ultimately, we might be able to inject RNA into patients and transform enough cells to activate the immune system against cancer without having to take cells out first," Majeti said. "That's science fiction __ this point, but that's the direction we are interested in going."


(17º§) The work was supported by funding from the Ludwig Foundation for Cancer Research, the Emerson Collective Cancer Research Fund, the New York Stem Cell Foundation, the Stinehart-Reed Foundation, the Leukemia and Lymphoma Society, the J. Benjamin Eckenhoff Fund, the Blavatnik Family Fellowship, the Deutsche Forschungsgemainshaft, the Knut and Alice Wallenberg Foundation, the Stanford Human Biology Research Exploration Program, the National Institutes of Health (grant F31CA196029), the American Society of Hematology, the A.P. Giannini Foundation, and the Stanford Cancer Institute.


(adapted)
med.stanford.edu/news/all-news/2023/03/cancer-hematology.html
PROFESSOR INGLÊS - 1 8
Regarding the format, how would you classify the text provided above?

ID: 1022703•
Inglês•
Interpretação de texto Reading comprehension•
IDCAP•
Prefeitura de Barra do Rocha BA•
Professor Fundamental Nível III Inglês•
2024

Which of the following statements best reflects the concept of linguistic variation in English as a global language, including the influence of netspeak?

ID: 1022706•
Inglês•
Interpretação de texto Reading comprehension•
IDCAP•
Prefeitura de Barra do Rocha BA•
Professor Fundamental Nível III Inglês•
2024

Which reading strategy is most suitable for identifying specific information in a complex infographic?

ID: 1022708•
Inglês•
Interpretação de texto Reading comprehension•
IDCAP•
Prefeitura de Barra do Rocha BA•
Professor Fundamental Nível III Inglês•
2024

Consider the dialogue below:

Anna: Hey, John, did you hear about the new project we are supposed to start next week?

John: Yes, but I'm not sure if I'm ready for it. I haven't even finished the current one.

Anna: Oh, I understand. I also feel overwhelmed. But did you talk to Mark about it?

John: Not yet. I know he is very busy, and I don't want to bother him.

Anna: I get it, but maybe if you explain your situation, he could give you more time.

John: Maybe you're right. I guess I'll give it a try. Thanks,

Anna. Anna: No worries! Good luck!

Based on the dialogue, what can we infer about John?

ID: 1024487•
Inglês•
Interpretação de texto Reading comprehension•
IDCAP•
OGMO Paranaguá PR•
Conferente•
2024

O texto seguinte servirá de base para responder à questão.


Manufacturing dips as container outlook slides


The NEOI fell to 48.9 in August from 49.6 in July, indicating deteriorating trade conditions for the third consecutive month. Traded goods slowed in both developed and emerging markets, but India maintained a modest growth in goods exports during August, the last month for which figures are available.

In addition, the global PMI has shown a contraction of manufacturing, signalling a further deterioration in cargo levels in the immediate future.

"China's goods exports fell for the first time in 2024, signalling a broader decline in manufacturing as the year progresses," said global freight forwarder Dimerco.

Headquartered in Taiwan, the Taipei-listed forwarder said that the Federal Reserve's recent interest rate cut may revive global goods trade.

August trading in the US continued to grow amid concerns about a US East Coast strike, and a November election that could see major import tariffs imposed on goods, said Dimerco.

"The early peak season suggests an earlier-than-usual start to the slow season, with expected declines in handling volume from September to December, projected at 2.31m, 2.08m, 1.92m, and 1.89m teu, respectively. If these forecasts hold, total port volume for 2024 could reach 24.98m teu, a 12% increase from 2023," said Alvin Fuh, VP - ocean freight at Dimerco Express Group.

Dynamar analyst Darron Wadey, said: "Approaching 470 vessels bringing around 3.2m teu in capacity are expected to be delivered by the end of 2024."

That massive increase in capacity, and the fact that much of this increase is for larger sized vessels, means that any correction in freight rates should have started up to a year ago, according to Wadey.

"It is only the happenstance of the Red Sea and US East Coast situations that have, artificially, buoyed the markets. When the markets do correct therefore, the falls will only be more dramatic because the inevitable has been delayed whilst the stream of new ships coming online continues," said Wadey.

Drewry Shipping Consultants' analysis shows that blank sailings are expected to increase between 9 September and 7 October with an additional 53 blanked sailings, totalling 90 for the period. Some 67% of these cancelled services were on the Pacific eastbound, while a further 21% on the Asia to Europe trades and 12% on the Atlantic.

Even with these cancelled services, rates are continuing to fall on all the major trades, according to Dimerco.

New entrants are said to be another element to failure of lines to maintain rate levels.

"While the three major alliances are increasing blank sailings, several individual carriers have deployed 11 extra vessels for Europe WB and 14 for TPEB to handle the expected cargo surge before China's Golden Week. However, the anticipated pre-October 1 cargo rush in China did not materialise this year, leaving no backlogs or rollover cargo for these extra loaders to transport," said Dimerco's monthly analysis.

Rebalancing trade can only be achieved through the long-term and steady growth of trade, said Wadey, combined with "a strategic rather than knee-jerk ship ordering policy". These required shifts are generational, he said, "in the short term, political events in the US might lead to an end-2024 rush for cargoes again... but then where does that leave 2025 and beyond?"

Drewry's WCI index fell a further 7% this week, closing at $3,691/feu.

https://www.seatrade-maritime.com/containers/manufacturing-dips-as-container-outlook-slides
According to the article, what is the significance of the NEOI dropping to 48.9 in August?

ID: 1024636•
Inglês•
Interpretação de texto Reading comprehension•
IDCAP•
Prefeitura de Vila Rica MT•
Inglês•
2023

Stanford Medicine scientists transform cancer cells into weapons against cancer

March 1, 2023 - By Christopher Vaughan


(1º§) Some cities fight gangs with ex-members whoeducate kids and starve gangs of new recruits. Stanford Medicine researchers have done something similar with cancer — altering cancer cells so that they teach the body's immune system to fight the very cancer the cells came from.


(2º§) "This approach could open up an entirely new therapeutic approach to treating cancer," said Ravi Majeti, MD, PhD, a professor of hematology and the study's senior author. The research was published March 1 in Cancer Discovery. The lead author is Miles Linde, PhD, a former PhD student in immunology who is now at the Fred Hutchinson Cancer Institute in Seattle.


(3º§) Some of the most promising cancer treatments use the patient's own immune system to attack the cancer, often __ taking the brakes off immune responses to cancer or by teaching the immune system to recognize and attack the cancer more vigorously. T cells, part of the immune system that learns to identify and attack new pathogens such as viruses, can be trained to recognize specific cancer antigens, which are proteins that generate an immune response.


(4º§) For instance, in CAR T-cell therapy, T cells are taken from a patient, programmed to recognize a specific cancer antigen, then returned to the patient. But there are many cancer antigens, and physicians sometimes need to guess which ones will be most potent.


(5º§) A better approach would be to train T cells to recognize cancer via processes that more closely mimic the way things naturally occur in the body — like the way a vaccine teaches the immune system to recognize pathogens. T cells learn to recognize pathogens because special antigen presenting cells (APCs) gather pieces of the pathogen and show them to the T cells in a way that tells the T cells, "Here is what the pathogen looks like — go get it."


(6º§) Something similar in cancer would be for APCs to gather up the many antigens that characterize a cancer cell. That way, instead of T cells being programmed to attack one or a few antigens, they are trained to recognize many cancer antigens and are more likely to wage a multipronged attack on the cancer.


(7º§) Now that researchers have become adept at transforming one kind of cell into another, Majeti and his colleagues had a hunch that if they turned cancer cells into a type of APC called macrophages, they would be naturally adept at teaching T cells what to attack.


(8º§) "We hypothesized that maybe cancer cells reprogrammed into macrophage cells could stimulate T cells because those APCs carry all the antigens of the cancer cells they came from," said Majeti, who is also the RZ Cao Professor, assistant director of the Institute for Stem Cell Biology and Regenerative Medicine and director of the Ludwig Center for Cancer Stem Cell Research and Medicine.


(9º§) The study builds on prior research from the Majeti lab showing that cells taken from patients with a type of acute leukemia could be converted into non-leukemic macrophages with many of the properties of APCs.


(10º§) In the current study, the researchers programmed mouse leukemia cells so that some of them could be induced to transform themselves into APCs. When they tested their cancer vaccine strategy on the mouse immune system, the mice successfully cleared the cancer.


(11º§) "When we first saw the data showing clearance of the leukemia in the mice __ working immune systems, we were blown away," Majeti said. "We couldn't believe it worked as well as it did."


(12º§) Other experiments showed that the cells created from cancer cells were indeed acting as antigen-presenting cells that sensitized T cells to the cancer. "What's more, we showed that the immune system remembered what these cells taught them," Majeti said. "When we reintroduced cancer to these mice over 100 days after the initial tumor inoculation, they still had a strong immunological response that protected them."


(13º§) "We wondered, If this works with leukemias, will it also work with solid tumors?" Majeti said. The team tested the same approach using mouse fibrosarcoma, breast cancer, and bone cancer. "The transformation of cancer cells from solid tumors was not as efficient, but we still observed positive results," Majeti said. With all three cancers, the creation of tumor-derived APCs led to significantly improved survival.


(14º§) Lastly, the researchers returned to the original type of acute leukemia. When the human leukemia cell-derived APCs were exposed to human T cells from the same patient, they observed all the signs that would be expected if the APCs were indeed teaching the T cells how to attack the leukemia.


(15º§) "We showed that reprogrammed tumor cells could lead to a durable and systemic attack on the cancer in mice and a similar response with human patient immune cells," Majeti said. "In the future we might be able to take out tumor cells, transform them into APCs and give them back to patients as a therapeutic cancer vaccine."


(16º§) "Ultimately, we might be able to inject RNA into patients and transform enough cells to activate the immune system against cancer without having to take cells out first," Majeti said. "That's science fiction __ this point, but that's the direction we are interested in going."


(17º§) The work was supported by funding from the Ludwig Foundation for Cancer Research, the Emerson Collective Cancer Research Fund, the New York Stem Cell Foundation, the Stinehart-Reed Foundation, the Leukemia and Lymphoma Society, the J. Benjamin Eckenhoff Fund, the Blavatnik Family Fellowship, the Deutsche Forschungsgemainshaft, the Knut and Alice Wallenberg Foundation, the Stanford Human Biology Research Exploration Program, the National Institutes of Health (grant F31CA196029), the American Society of Hematology, the A.P. Giannini Foundation, and the Stanford Cancer Institute.


(adapted)
med.stanford.edu/news/all-news/2023/03/cancer-hematology.html
PROFESSOR INGLÊS - 1 8
What groundbreaking approach to cancer treatment does the research discuss?

ID: 1024645•
Inglês•
Interpretação de texto Reading comprehension•
IDCAP•
Prefeitura de Vila Rica MT•
Inglês•
2023

What evidence from the research supports the potential application of the developed cancer vaccine strategy?

ID: 1024479•
Inglês•
Interpretação de texto Reading comprehension•
IDCAP•
OGMO Paranaguá PR•
Estivador•
2024

O texto seguinte servirá de base para responder à questão.


Ship carrying explosive fertiliser heads to UK waters


A Maltese-flagged cargo ship carrying thousands of tonnes of potentially explosive fertiliser is set to travel through UK waters.

Ruby, which was earlier accompanied by an escort tug, has reportedly been rejected by several countries due to its cargo.

The ship, which has 20,000 tonnes of ammonium nitrate on board, was previously damaged but deemed seaworthy by authorities in Norway.

HM Coastguard is in contact with the vessel, which according to ship tracking data, was in the North Sea off the Kent coast on Thursday morning.

The ship, owned by Maltese firm Ruby Enterprise, set off from the northern Russian port of Kandalaksha in July.

The national maritime emergency service said it will monitor the ship's progress as it heads towards and through UK waters.

Vessels are not required to ask permission to travel through UK territorial waters for legitimate purposes.

An escorting tug, Amber II, which had sailed with the boat from Norway, left the Ruby on Thursday morning and sailed east. Its current destination is listed as Rotterdam, in the Netherlands.

Though there is no suggestion of immediate danger from the cargo, the same chemical caused a devastating blast at a Beirut warehouse in 2020.

Ammonium nitrate is regularly transported around the world and used as fertiliser but is also used in explosives.

The ship is carrying seven times the amount of ammonium nitrate that caused the Beirut explosion.

Ruby's location on Thursday, according to Marine Traffic. Marine Traffic data suggested the ship was in the North Sea on Thursday.

Soon after departing Russia, the Ruby briefly ran aground after reportedly encountering a storm.

It then continued its journey around the Kola Peninsula and docked in Tromsø, Norway.

Norway's Maritime Authority told the BBC the vessel was inspected by DNV Group to ensure it met safety and environmental standards.

The group found damage to its hull, propeller and rudder, but the Ruby was still deemed "seaworthy".

As a precaution, DNV Group, and the Maltese flag registry, insisted that a tug escort the vessel for the remainder of its journey.

The ship was bound for Klaipeda, in Lithuania, according to ship tracking firm MarineTraffic.

But despite being deemed seaworthy, the ship was denied entry to Klaipeda. Algia Latakas, the port authority's chief executive, told the BBC that this was "because of its cargo".

Andrea Sella, professor of chemistry at University College London, said the cargo was not high risk, unless there was a fire on board.

"While I understand the caution of the authorities in Troms, I suspect that the chances of a similar disaster to Beirut are relatively modest," she said.

She added: "It would also be interesting to know what the nature of the repairs might be as clearly welding might significantly raise the potential fire risk."

Other reports suggested Sweden had imposed a ban as well, but Sweden's transport agency denies this.

"What the Swedish authorities did was to follow the matter in case we would have needed to act in some way," a spokesperson told the BBC.

In recent weeks, the Ruby travelled south along Norway's coast and through the North Sea.

The ship reportedly has had restricted manoeuvrability, though the BBC has been unable to confirm this.

On 25 September, it anchored about 15 miles (25km) north east of Margate, in Kent, near the Dover Strait - one of the world's busiest waterways.

The Maritime and Coastguard Agency (MCA) said the vessel is "currently securely anchored outside UK territorial waters waiting for appropriate conditions to refuel at sea before passing through the English Channel".

Refuelling at sea is a common practice and will take place in accordance with safety procedures and in favourable weather, said the MCA.

Its current destination is listed as Marsaxlokk, in Malta.

But Maltese authorities have told local media that the ship can only enter the country if it empties its cargo beforehand.

Marco Forgione, director general of the Chartered Institute of Export & International Trade, raised concerns about potential "environmental damage".

"Should the ammonium nitrate start to leak out of the ship and contaminate the sea... shipping through the channel would have to be diverted to avoid further shifting the pollution through its waters," he said.

He added that damage as a result of the potential scenario would be "immense" and cause "ongoing disruption".

The vessel has appropriate safety certificates approved by the vessel's flag state and is able to make its own way, said the MCA.

https://www.bbc.com/news/articles/c62g95721leo

Which statement best describes the condition of the Ruby when it was inspected in Norway?

ID: 1024484•
Inglês•
Interpretação de texto Reading comprehension•
IDCAP•
OGMO Paranaguá PR•
Arrumador•
2024

O texto seguinte servirá de base para responder à questão.


Manufacturing dips as container outlook slides


The NEOI fell to 48.9 in August from 49.6 in July, indicating deteriorating trade conditions for the third consecutive month. Traded goods slowed in both developed and emerging markets, but India maintained a modest growth in goods exports during August, the last month for which figures are available.

In addition, the global PMI has shown a contraction of manufacturing, signalling a further deterioration in cargo levels in the immediate future.

"China's goods exports fell for the first time in 2024, signalling a broader decline in manufacturing as the year progresses," said global freight forwarder Dimerco.

Headquartered in Taiwan, the Taipei-listed forwarder said that the Federal Reserve's recent interest rate cut may revive global goods trade.

August trading in the US continued to grow amid concerns about a US East Coast strike, and a November election that could see major import tariffs imposed on goods, said Dimerco.

"The early peak season suggests an earlier-than-usual start to the slow season, with expected declines in handling volume from September to December, projected at 2.31m, 2.08m, 1.92m, and 1.89m teu, respectively. If these forecasts hold, total port volume for 2024 could reach 24.98m teu, a 12% increase from 2023," said Alvin Fuh, VP - ocean freight at Dimerco Express Group.

Dynamar analyst Darron Wadey, said: "Approaching 470 vessels bringing around 3.2m teu in capacity are expected to be delivered by the end of 2024."

That massive increase in capacity, and the fact that much of this increase is for larger sized vessels, means that any correction in freight rates should have started up to a year ago, according to Wadey.

"It is only the happenstance of the Red Sea and US East Coast situations that have, artificially, buoyed the markets. When the markets do correct therefore, the falls will only be more dramatic because the inevitable has been delayed whilst the stream of new ships coming online continues," said Wadey.

Drewry Shipping Consultants' analysis shows that blank sailings are expected to increase between 9 September and 7 October with an additional 53 blanked sailings, totalling 90 for the period. Some 67% of these cancelled services were on the Pacific eastbound, while a further 21% on the Asia to Europe trades and 12% on the Atlantic.

Even with these cancelled services, rates are continuing to fall on all the major trades, according to Dimerco.

New entrants are said to be another element to failure of lines to maintain rate levels.

"While the three major alliances are increasing blank sailings, several individual carriers have deployed 11 extra vessels for Europe WB and 14 for TPEB to handle the expected cargo surge before China's Golden Week. However, the anticipated pre-October 1 cargo rush in China did not materialise this year, leaving no backlogs or rollover cargo for these extra loaders to transport," said Dimerco's monthly analysis.

Rebalancing trade can only be achieved through the long-term and steady growth of trade, said Wadey, combined with "a strategic rather than knee-jerk ship ordering policy". These required shifts are generational, he said, "in the short term, political events in the US might lead to an end-2024 rush for cargoes again... but then where does that leave 2025 and beyond?"

Drewry's WCI index fell a further 7% this week, closing at $3,691/feu.

https://www.seatrade-maritime.com/containers/manufacturing-dips-as-c ontainer-outlook-slides
What is the projected handling volume decline for the period from September to December, according to Dimerco?

ID: 1024634•
Inglês•
Interpretação de texto Reading comprehension•
IDCAP•
Prefeitura de Vila Rica MT•
Inglês•
2023

Stanford Medicine scientists transform cancer cells into weapons against cancer

March 1, 2023 - By Christopher Vaughan


(1º§) Some cities fight gangs with ex-members whoeducate kids and starve gangs of new recruits. Stanford Medicine researchers have done something similar with cancer — altering cancer cells so that they teach the body's immune system to fight the very cancer the cells came from.


(2º§) "This approach could open up an entirely new therapeutic approach to treating cancer," said Ravi Majeti, MD, PhD, a professor of hematology and the study's senior author. The research was published March 1 in Cancer Discovery. The lead author is Miles Linde, PhD, a former PhD student in immunology who is now at the Fred Hutchinson Cancer Institute in Seattle.


(3º§) Some of the most promising cancer treatments use the patient's own immune system to attack the cancer, often __ taking the brakes off immune responses to cancer or by teaching the immune system to recognize and attack the cancer more vigorously. T cells, part of the immune system that learns to identify and attack new pathogens such as viruses, can be trained to recognize specific cancer antigens, which are proteins that generate an immune response.


(4º§) For instance, in CAR T-cell therapy, T cells are taken from a patient, programmed to recognize a specific cancer antigen, then returned to the patient. But there are many cancer antigens, and physicians sometimes need to guess which ones will be most potent.


(5º§) A better approach would be to train T cells to recognize cancer via processes that more closely mimic the way things naturally occur in the body — like the way a vaccine teaches the immune system to recognize pathogens. T cells learn to recognize pathogens because special antigen presenting cells (APCs) gather pieces of the pathogen and show them to the T cells in a way that tells the T cells, "Here is what the pathogen looks like — go get it."


(6º§) Something similar in cancer would be for APCs to gather up the many antigens that characterize a cancer cell. That way, instead of T cells being programmed to attack one or a few antigens, they are trained to recognize many cancer antigens and are more likely to wage a multipronged attack on the cancer.


(7º§) Now that researchers have become adept at transforming one kind of cell into another, Majeti and his colleagues had a hunch that if they turned cancer cells into a type of APC called macrophages, they would be naturally adept at teaching T cells what to attack.


(8º§) "We hypothesized that maybe cancer cells reprogrammed into macrophage cells could stimulate T cells because those APCs carry all the antigens of the cancer cells they came from," said Majeti, who is also the RZ Cao Professor, assistant director of the Institute for Stem Cell Biology and Regenerative Medicine and director of the Ludwig Center for Cancer Stem Cell Research and Medicine.


(9º§) The study builds on prior research from the Majeti lab showing that cells taken from patients with a type of acute leukemia could be converted into non-leukemic macrophages with many of the properties of APCs.


(10º§) In the current study, the researchers programmed mouse leukemia cells so that some of them could be induced to transform themselves into APCs. When they tested their cancer vaccine strategy on the mouse immune system, the mice successfully cleared the cancer.


(11º§) "When we first saw the data showing clearance of the leukemia in the mice __ working immune systems, we were blown away," Majeti said. "We couldn't believe it worked as well as it did."


(12º§) Other experiments showed that the cells created from cancer cells were indeed acting as antigen-presenting cells that sensitized T cells to the cancer. "What's more, we showed that the immune system remembered what these cells taught them," Majeti said. "When we reintroduced cancer to these mice over 100 days after the initial tumor inoculation, they still had a strong immunological response that protected them."


(13º§) "We wondered, If this works with leukemias, will it also work with solid tumors?" Majeti said. The team tested the same approach using mouse fibrosarcoma, breast cancer, and bone cancer. "The transformation of cancer cells from solid tumors was not as efficient, but we still observed positive results," Majeti said. With all three cancers, the creation of tumor-derived APCs led to significantly improved survival.


(14º§) Lastly, the researchers returned to the original type of acute leukemia. When the human leukemia cell-derived APCs were exposed to human T cells from the same patient, they observed all the signs that would be expected if the APCs were indeed teaching the T cells how to attack the leukemia.


(15º§) "We showed that reprogrammed tumor cells could lead to a durable and systemic attack on the cancer in mice and a similar response with human patient immune cells," Majeti said. "In the future we might be able to take out tumor cells, transform them into APCs and give them back to patients as a therapeutic cancer vaccine."


(16º§) "Ultimately, we might be able to inject RNA into patients and transform enough cells to activate the immune system against cancer without having to take cells out first," Majeti said. "That's science fiction __ this point, but that's the direction we are interested in going."


(17º§) The work was supported by funding from the Ludwig Foundation for Cancer Research, the Emerson Collective Cancer Research Fund, the New York Stem Cell Foundation, the Stinehart-Reed Foundation, the Leukemia and Lymphoma Society, the J. Benjamin Eckenhoff Fund, the Blavatnik Family Fellowship, the Deutsche Forschungsgemainshaft, the Knut and Alice Wallenberg Foundation, the Stanford Human Biology Research Exploration Program, the National Institutes of Health (grant F31CA196029), the American Society of Hematology, the A.P. Giannini Foundation, and the Stanford Cancer Institute.


(adapted)
med.stanford.edu/news/all-news/2023/03/cancer-hematology.html
PROFESSOR INGLÊS - 1 8
According to the study, how do the transformed cancer cells contribute to the immune system's response against cancer?

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Read the dialogue below:

Supervisor: Make sure the crane is ready for the container unloading. The cargo manifest shows we have 50 containers arriving today.
Dockworker: Understood. We'll start as soon as the ship finishes berthing at the quay.
Supervisor: Also, double-check the gangway. We need it in place for safe crew access once the ship is docked.
Dockworker: Sure thing. The stevedoring team is on standby for unloading, and the containers will be moved to the warehouse afterward.
Supervisor: Great. Keep an eye on the draught of the ship as well; we don't want any issues with the water depth during unloading.
Dockworker: Will do! I'll make sure everything goes smoothly once the customs clearance is done.
Which of the following terms refers to the process of checking a ship's cargo to ensure it complies with legal regulations before it can be unloaded?

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In the context of respiratory physiotherapy, which of the alternatives below correctly describes one of the objectives of this therapeutic practice?

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O texto seguinte servirá de base para responder à questão.


Ship carrying explosive fertiliser heads to UK waters


A Maltese-flagged cargo ship carrying thousands of tonnes of potentially explosive fertiliser is set to travel through UK waters.

Ruby, which was earlier accompanied by an escort tug, has reportedly been rejected by several countries due to its cargo.

The ship, which has 20,000 tonnes of ammonium nitrate on board, was previously damaged but deemed seaworthy by authorities in Norway.

HM Coastguard is in contact with the vessel, which according to ship tracking data, was in the North Sea off the Kent coast on Thursday morning.

The ship, owned by Maltese firm Ruby Enterprise, set off from the northern Russian port of Kandalaksha in July.

The national maritime emergency service said it will monitor the ship's progress as it heads towards and through UK waters.

Vessels are not required to ask permission to travel through UK territorial waters for legitimate purposes.

An escorting tug, Amber II, which had sailed with the boat from Norway, left the Ruby on Thursday morning and sailed east. Its current destination is listed as Rotterdam, in the Netherlands.

Though there is no suggestion of immediate danger from the cargo, the same chemical caused a devastating blast at a Beirut warehouse in 2020.

Ammonium nitrate is regularly transported around the world and used as fertiliser but is also used in explosives.

The ship is carrying seven times the amount of ammonium nitrate that caused the Beirut explosion.

Ruby's location on Thursday, according to Marine Traffic. Marine Traffic data suggested the ship was in the North Sea on Thursday.

Soon after departing Russia, the Ruby briefly ran aground after reportedly encountering a storm.

It then continued its journey around the Kola Peninsula and docked in Tromsø, Norway.

Norway's Maritime Authority told the BBC the vessel was inspected by DNV Group to ensure it met safety and environmental standards.

The group found damage to its hull, propeller and rudder, but the Ruby was still deemed "seaworthy".

As a precaution, DNV Group, and the Maltese flag registry, insisted that a tug escort the vessel for the remainder of its journey.

The ship was bound for Klaipeda, in Lithuania, according to ship tracking firm MarineTraffic.

But despite being deemed seaworthy, the ship was denied entry to Klaipeda. Algia Latakas, the port authority's chief executive, told the BBC that this was "because of its cargo".

Andrea Sella, professor of chemistry at University College London, said the cargo was not high risk, unless there was a fire on board.

"While I understand the caution of the authorities in Troms, I suspect that the chances of a similar disaster to Beirut are relatively modest," she said.

She added: "It would also be interesting to know what the nature of the repairs might be as clearly welding might significantly raise the potential fire risk."

Other reports suggested Sweden had imposed a ban as well, but Sweden's transport agency denies this.

"What the Swedish authorities did was to follow the matter in case we would have needed to act in some way," a spokesperson told the BBC.

In recent weeks, the Ruby travelled south along Norway's coast and through the North Sea.

The ship reportedly has had restricted manoeuvrability, though the BBC has been unable to confirm this.

On 25 September, it anchored about 15 miles (25km) north east of Margate, in Kent, near the Dover Strait - one of the world's busiest waterways.

The Maritime and Coastguard Agency (MCA) said the vessel is "currently securely anchored outside UK territorial waters waiting for appropriate conditions to refuel at sea before passing through the English Channel".

Refuelling at sea is a common practice and will take place in accordance with safety procedures and in favourable weather, said the MCA.

Its current destination is listed as Marsaxlokk, in Malta.

But Maltese authorities have told local media that the ship can only enter the country if it empties its cargo beforehand.

Marco Forgione, director general of the Chartered Institute of Export & International Trade, raised concerns about potential "environmental damage".

"Should the ammonium nitrate start to leak out of the ship and contaminate the sea... shipping through the channel would have to be diverted to avoid further shifting the pollution through its waters," he said.

He added that damage as a result of the potential scenario would be "immense" and cause "ongoing disruption".

The vessel has appropriate safety certificates approved by the vessel's flag state and is able to make its own way, said the MCA.

https://www.bbc.com/news/articles/c62g95721leo

What caused the authorities in Klaipeda, Lithuania, to deny entry to the Ruby?

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O texto seguinte servirá de base para responder à questão.


Ship carrying explosive fertiliser heads to UK waters


A Maltese-flagged cargo ship carrying thousands of tonnes of potentially explosive fertiliser is set to travel through UK waters.

Ruby, which was earlier accompanied by an escort tug, has reportedly been rejected by several countries due to its cargo.

The ship, which has 20,000 tonnes of ammonium nitrate on board, was previously damaged but deemed seaworthy by authorities in Norway.

HM Coastguard is in contact with the vessel, which according to ship tracking data, was in the North Sea off the Kent coast on Thursday morning.

The ship, owned by Maltese firm Ruby Enterprise, set off from the northern Russian port of Kandalaksha in July.

The national maritime emergency service said it will monitor the ship's progress as it heads towards and through UK waters.

Vessels are not required to ask permission to travel through UK territorial waters for legitimate purposes.

An escorting tug, Amber II, which had sailed with the boat from Norway, left the Ruby on Thursday morning and sailed east. Its current destination is listed as Rotterdam, in the Netherlands.

Though there is no suggestion of immediate danger from the cargo, the same chemical caused a devastating blast at a Beirut warehouse in 2020.

Ammonium nitrate is regularly transported around the world and used as fertiliser but is also used in explosives.

The ship is carrying seven times the amount of ammonium nitrate that caused the Beirut explosion.

Ruby's location on Thursday, according to Marine Traffic. Marine Traffic data suggested the ship was in the North Sea on Thursday.

Soon after departing Russia, the Ruby briefly ran aground after reportedly encountering a storm.

It then continued its journey around the Kola Peninsula and docked in Tromsø, Norway.

Norway's Maritime Authority told the BBC the vessel was inspected by DNV Group to ensure it met safety and environmental standards.

The group found damage to its hull, propeller and rudder, but the Ruby was still deemed "seaworthy".

As a precaution, DNV Group, and the Maltese flag registry, insisted that a tug escort the vessel for the remainder of its journey.

The ship was bound for Klaipeda, in Lithuania, according to ship tracking firm MarineTraffic.

But despite being deemed seaworthy, the ship was denied entry to Klaipeda. Algia Latakas, the port authority's chief executive, told the BBC that this was "because of its cargo".

Andrea Sella, professor of chemistry at University College London, said the cargo was not high risk, unless there was a fire on board.

"While I understand the caution of the authorities in Troms, I suspect that the chances of a similar disaster to Beirut are relatively modest," she said.

She added: "It would also be interesting to know what the nature of the repairs might be as clearly welding might significantly raise the potential fire risk."

Other reports suggested Sweden had imposed a ban as well, but Sweden's transport agency denies this.

"What the Swedish authorities did was to follow the matter in case we would have needed to act in some way," a spokesperson told the BBC.

In recent weeks, the Ruby travelled south along Norway's coast and through the North Sea.

The ship reportedly has had restricted manoeuvrability, though the BBC has been unable to confirm this.

On 25 September, it anchored about 15 miles (25km) north east of Margate, in Kent, near the Dover Strait - one of the world's busiest waterways.

The Maritime and Coastguard Agency (MCA) said the vessel is "currently securely anchored outside UK territorial waters waiting for appropriate conditions to refuel at sea before passing through the English Channel".

Refuelling at sea is a common practice and will take place in accordance with safety procedures and in favourable weather, said the MCA.

Its current destination is listed as Marsaxlokk, in Malta.

But Maltese authorities have told local media that the ship can only enter the country if it empties its cargo beforehand.

Marco Forgione, director general of the Chartered Institute of Export & International Trade, raised concerns about potential "environmental damage".

"Should the ammonium nitrate start to leak out of the ship and contaminate the sea... shipping through the channel would have to be diverted to avoid further shifting the pollution through its waters," he said.

He added that damage as a result of the potential scenario would be "immense" and cause "ongoing disruption".

The vessel has appropriate safety certificates approved by the vessel's flag state and is able to make its own way, said the MCA.

https://www.bbc.com/news/articles/c62g95721leo

What is the main concern regarding the Ruby cargo ship as it travels through UK waters?

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O texto seguinte servirá de base para responder à questão.


Ship carrying explosive fertiliser heads to UK waters


A Maltese-flagged cargo ship carrying thousands of tonnes of potentially explosive fertiliser is set to travel through UK waters.

Ruby, which was earlier accompanied by an escort tug, has reportedly been rejected by several countries due to its cargo.

The ship, which has 20,000 tonnes of ammonium nitrate on board, was previously damaged but deemed seaworthy by authorities in Norway.

HM Coastguard is in contact with the vessel, which according to ship tracking data, was in the North Sea off the Kent coast on Thursday morning.

The ship, owned by Maltese firm Ruby Enterprise, set off from the northern Russian port of Kandalaksha in July.

The national maritime emergency service said it will monitor the ship's progress as it heads towards and through UK waters.

Vessels are not required to ask permission to travel through UK territorial waters for legitimate purposes.

An escorting tug, Amber II, which had sailed with the boat from Norway, left the Ruby on Thursday morning and sailed east. Its current destination is listed as Rotterdam, in the Netherlands.

Though there is no suggestion of immediate danger from the cargo, the same chemical caused a devastating blast at a Beirut warehouse in 2020.

Ammonium nitrate is regularly transported around the world and used as fertiliser but is also used in explosives.

The ship is carrying seven times the amount of ammonium nitrate that caused the Beirut explosion.

Ruby's location on Thursday, according to Marine Traffic. Marine Traffic data suggested the ship was in the North Sea on Thursday.

Soon after departing Russia, the Ruby briefly ran aground after reportedly encountering a storm.

It then continued its journey around the Kola Peninsula and docked in Tromsø, Norway.

Norway's Maritime Authority told the BBC the vessel was inspected by DNV Group to ensure it met safety and environmental standards.

The group found damage to its hull, propeller and rudder, but the Ruby was still deemed "seaworthy".

As a precaution, DNV Group, and the Maltese flag registry, insisted that a tug escort the vessel for the remainder of its journey.

The ship was bound for Klaipeda, in Lithuania, according to ship tracking firm MarineTraffic.

But despite being deemed seaworthy, the ship was denied entry to Klaipeda. Algia Latakas, the port authority's chief executive, told the BBC that this was "because of its cargo".

Andrea Sella, professor of chemistry at University College London, said the cargo was not high risk, unless there was a fire on board.

"While I understand the caution of the authorities in Troms, I suspect that the chances of a similar disaster to Beirut are relatively modest," she said.

She added: "It would also be interesting to know what the nature of the repairs might be as clearly welding might significantly raise the potential fire risk."

Other reports suggested Sweden had imposed a ban as well, but Sweden's transport agency denies this.

"What the Swedish authorities did was to follow the matter in case we would have needed to act in some way," a spokesperson told the BBC.

In recent weeks, the Ruby travelled south along Norway's coast and through the North Sea.

The ship reportedly has had restricted manoeuvrability, though the BBC has been unable to confirm this.

On 25 September, it anchored about 15 miles (25km) north east of Margate, in Kent, near the Dover Strait - one of the world's busiest waterways.

The Maritime and Coastguard Agency (MCA) said the vessel is "currently securely anchored outside UK territorial waters waiting for appropriate conditions to refuel at sea before passing through the English Channel".

Refuelling at sea is a common practice and will take place in accordance with safety procedures and in favourable weather, said the MCA.

Its current destination is listed as Marsaxlokk, in Malta.

But Maltese authorities have told local media that the ship can only enter the country if it empties its cargo beforehand.

Marco Forgione, director general of the Chartered Institute of Export & International Trade, raised concerns about potential "environmental damage".

"Should the ammonium nitrate start to leak out of the ship and contaminate the sea... shipping through the channel would have to be diverted to avoid further shifting the pollution through its waters," he said.

He added that damage as a result of the potential scenario would be "immense" and cause "ongoing disruption".

The vessel has appropriate safety certificates approved by the vessel's flag state and is able to make its own way, said the MCA.

https://www.bbc.com/news/articles/c62g95721leo

Why was the ship Ruby initially escorted by a tug?

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O texto seguinte servirá de base para responder à questão.


Manufacturing dips as container outlook slides


The NEOI fell to 48.9 in August from 49.6 in July, indicating deteriorating trade conditions for the third consecutive month. Traded goods slowed in both developed and emerging markets, but India maintained a modest growth in goods exports during August, the last month for which figures are available.

In addition, the global PMI has shown a contraction of manufacturing, signalling a further deterioration in cargo levels in the immediate future.

"China's goods exports fell for the first time in 2024, signalling a broader decline in manufacturing as the year progresses," said global freight forwarder Dimerco.

Headquartered in Taiwan, the Taipei-listed forwarder said that the Federal Reserve's recent interest rate cut may revive global goods trade.

August trading in the US continued to grow amid concerns about a US East Coast strike, and a November election that could see major import tariffs imposed on goods, said Dimerco.

"The early peak season suggests an earlier-than-usual start to the slow season, with expected declines in handling volume from September to December, projected at 2.31m, 2.08m, 1.92m, and 1.89m teu, respectively. If these forecasts hold, total port volume for 2024 could reach 24.98m teu, a 12% increase from 2023," said Alvin Fuh, VP - ocean freight at Dimerco Express Group.

Dynamar analyst Darron Wadey, said: "Approaching 470 vessels bringing around 3.2m teu in capacity are expected to be delivered by the end of 2024."

That massive increase in capacity, and the fact that much of this increase is for larger sized vessels, means that any correction in freight rates should have started up to a year ago, according to Wadey.

"It is only the happenstance of the Red Sea and US East Coast situations that have, artificially, buoyed the markets. When the markets do correct therefore, the falls will only be more dramatic because the inevitable has been delayed whilst the stream of new ships coming online continues," said Wadey.

Drewry Shipping Consultants' analysis shows that blank sailings are expected to increase between 9 September and 7 October with an additional 53 blanked sailings, totalling 90 for the period. Some 67% of these cancelled services were on the Pacific eastbound, while a further 21% on the Asia to Europe trades and 12% on the Atlantic.

Even with these cancelled services, rates are continuing to fall on all the major trades, according to Dimerco.

New entrants are said to be another element to failure of lines to maintain rate levels.

"While the three major alliances are increasing blank sailings, several individual carriers have deployed 11 extra vessels for Europe WB and 14 for TPEB to handle the expected cargo surge before China's Golden Week. However, the anticipated pre-October 1 cargo rush in China did not materialise this year, leaving no backlogs or rollover cargo for these extra loaders to transport," said Dimerco's monthly analysis.

Rebalancing trade can only be achieved through the long-term and steady growth of trade, said Wadey, combined with "a strategic rather than knee-jerk ship ordering policy". These required shifts are generational, he said, "in the short term, political events in the US might lead to an end-2024 rush for cargoes again... but then where does that leave 2025 and beyond?"

Drewry's WCI index fell a further 7% this week, closing at $3,691/feu.

https://www.seatrade-maritime.com/containers/manufacturing-dips-as-c ontainer-outlook-slides
What reason does the article give for the failure of shipping lines to maintain rate levels, despite efforts to manage capacity through blank sailings?

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Dr. Joy, an experienced physiotherapist, is preparing a presentation for a physiotherapy conference. He would like to include a real case study to illustrate an important point about the effectiveness of a specific technique. During the presentation, Dr. Joy mentions identifiable details and displays images of a client he treated, without having obtained formal authorization from the client or their legal guardian. Dr. Joy believes that using this information will enrich the presentation and promote the technique. Based on ethical standards for physiotherapists, which of Dr. Joy's actions is prohibited?
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