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T E X T
Can you learn in your sleep?
Sleep is known to be crucial for learning and memory formation. What's more, scientists have even managed to pick out specific memories and consolidate them during sleep. However, the exact mechanisms behind this were unknown — until now.
Those among us who grew up with the popular cartoon "Dexter's Laboratory" might remember the famous episode wherein Dexter's trying to learn French overnight. He creates a device that helps him to learn in his sleep by playing French phrases to him. Of course, since the show is a comedy, Dexter's record gets stuck on the phrase "Omelette du fromage" and the next day he's incapable of saying anything else. This is, of course, a problem that puts him through a series of hilarious situations.
The idea that we can learn in our sleep has captivated the minds of artists and scientists alike; the possibility that one day we could all drastically improve our productivity by learning in our sleep is very appealing. But could such a scenario ever become a reality?
New research seems to suggest so, and scientists in general are moving closer to understanding precisely what goes on in the brain when we sleep and how the restful state affects learning and memory formation.
For instance, previous studies have shown that non-rapid eye movement (non-REM) sleep — or dreamless sleep — is crucial for consolidating memories. It has also been shown that sleep spindles, or sudden spikes in oscillatory brain activity that canbe seen on an electroencephalogram (EEG) during the second stage of non-REM sleep, are key for this memory consolidation. Scientists were also able to specifically target certain memories and reactivate, or strengthen, them by using auditory cues.
However, the mechanism behind such achievements remained mysterious until now. Researchers were also unaware if such mechanisms would help with memorizing new information.
Therefore, a team of researchers set out to investigate. Scott Cairney, from the University of York in the United Kingdom, co-led the research with Bernhard Staresina, who works at the University of Birmingham, also in the U.K. Their findings were published in the journal Current Biology.
Cairney explains the motivation for the research, saying, "We are quite certain that memories are reactivated in the brain during sleep, but we don't know the neural processes that underpin this phenomenon." "Sleep spindles," he continues, "have been linked to the benefits of sleep for memory in previous research, so we wanted to investigate whether these brain waves mediate reactivation. If they support memory reactivation, we further reasoned that it could be possible to decipher memory signals at the time that these spindles took place."
To test their hypotheses, Cairney and his colleagues asked 46 participants "to learn associations between words and pictures of objects or scenes before a nap." Afterward, some of the participants took a 90-minute nap, whereas others stayed awake. To those who napped, "Half of the words were [...] replayed during the nap to trigger the reactivation of the newly learned picture memories," explains Cairney.
"When the participants woke after a good period of sleep," he says, "we presented them again with the words and asked them to recall the object and scene pictures. We found that their memory was better for the pictures that were connected to the words that were presented in sleep, compared to those words that weren't," Cairney reports.
Using an EEG machine, the researchers were also able to see that playing the associated words to reactivate memories triggered sleep spindles in the participants' brains. More specifically, the EEG sleep spindle patterns "told" the researchers whether the participants were processing memories related to objects or memories related to scenes.
"Our data suggest that spindles facilitate processing of relevant memory features during sleep and that this process boosts memory consolidation," says Staresina. "While it has been shown previously," he continues, "that targeted memory reactivation can boost memory consolidation during sleep, we now show that sleep spindles might represent the key underlying mechanism."
Cairney adds, "When you are awake you learn new things, but when you are asleep you refine them, making it easier to retrieve them and apply them correctly when you need them the most. This is important for how we learn but also for how we might help retain healthy brain functions."
Staresina suggests that this newly gained knowledge could lead to effective strategies for boosting memory while sleeping.
So, though learning things from scratch à la "Dexter's Lab" may take a while to become a reality, we can safely say that our brains continue to learn while we sleep, and that researchers just got a lot closer to understanding why this happens.
From: https://www.medicalnewstoday.com/articles/Mar/2018
(S. Bernardo, 1996.)
No grande setor agropecuário, alimentar e energético do Brasil, podem ser identificados diversos ramos e produtos específicos, cada um apresentando sua configuração regional e conformando seu próprio circuito espacial produtivo. Com base nesse tema, relacione corretamente os produtos apresentados a seguir com suas respectivas distribuições geográficas, numerando a Coluna II de acordo com a Coluna I.
Coluna I
1. Soja
2. Cana-deaçúcar
3. Café
4. Fruticultura
Coluna II
( ) Pela necessidade abundante de água para garantir a sua produção, ocupa, especialmente no sertão nordestino, os vales dos rios São Francisco, Açu e Jaguaribe, onde encontra o ambiente apropriado para uma produtividade ampliada.
( ) É hoje uma das principais commodities do agronegócio brasileiro, com sua produção ocupando regiões tradicionais de plantio no Sul do Brasil que se estenderam aos cerrados do Centro-Oeste e do Nordeste do país.
( ) Símbolo da produção agroexportadora brasileira no período colonial, foi, durante séculos, quase um monopólio da região Nordeste, tendo hoje o estado de São Paulo como seu maior e mais moderno produtor.
( ) Até há poucas décadas era produzido principalmente no estado de São Paulo e no norte do Paraná, mas mudou seu centro de produção para Minas Gerais e para polos secundários no Espírito Santo, Bahia e Rondônia.
A sequência correta, de cima para baixo, é:
T E X T
Can you learn in your sleep?
Sleep is known to be crucial for learning and memory formation. What's more, scientists have even managed to pick out specific memories and consolidate them during sleep. However, the exact mechanisms behind this were unknown — until now.
Those among us who grew up with the popular cartoon "Dexter's Laboratory" might remember the famous episode wherein Dexter's trying to learn French overnight. He creates a device that helps him to learn in his sleep by playing French phrases to him. Of course, since the show is a comedy, Dexter's record gets stuck on the phrase "Omelette du fromage" and the next day he's incapable of saying anything else. This is, of course, a problem that puts him through a series of hilarious situations.
The idea that we can learn in our sleep has captivated the minds of artists and scientists alike; the possibility that one day we could all drastically improve our productivity by learning in our sleep is very appealing. But could such a scenario ever become a reality?
New research seems to suggest so, and scientists in general are moving closer to understanding precisely what goes on in the brain when we sleep and how the restful state affects learning and memory formation.
For instance, previous studies have shown that non-rapid eye movement (non-REM) sleep — or dreamless sleep — is crucial for consolidating memories. It has also been shown that sleep spindles, or sudden spikes in oscillatory brain activity that canbe seen on an electroencephalogram (EEG) during the second stage of non-REM sleep, are key for this memory consolidation. Scientists were also able to specifically target certain memories and reactivate, or strengthen, them by using auditory cues.
However, the mechanism behind such achievements remained mysterious until now. Researchers were also unaware if such mechanisms would help with memorizing new information.
Therefore, a team of researchers set out to investigate. Scott Cairney, from the University of York in the United Kingdom, co-led the research with Bernhard Staresina, who works at the University of Birmingham, also in the U.K. Their findings were published in the journal Current Biology.
Cairney explains the motivation for the research, saying, "We are quite certain that memories are reactivated in the brain during sleep, but we don't know the neural processes that underpin this phenomenon." "Sleep spindles," he continues, "have been linked to the benefits of sleep for memory in previous research, so we wanted to investigate whether these brain waves mediate reactivation. If they support memory reactivation, we further reasoned that it could be possible to decipher memory signals at the time that these spindles took place."
To test their hypotheses, Cairney and his colleagues asked 46 participants "to learn associations between words and pictures of objects or scenes before a nap." Afterward, some of the participants took a 90-minute nap, whereas others stayed awake. To those who napped, "Half of the words were [...] replayed during the nap to trigger the reactivation of the newly learned picture memories," explains Cairney.
"When the participants woke after a good period of sleep," he says, "we presented them again with the words and asked them to recall the object and scene pictures. We found that their memory was better for the pictures that were connected to the words that were presented in sleep, compared to those words that weren't," Cairney reports.
Using an EEG machine, the researchers were also able to see that playing the associated words to reactivate memories triggered sleep spindles in the participants' brains. More specifically, the EEG sleep spindle patterns "told" the researchers whether the participants were processing memories related to objects or memories related to scenes.
"Our data suggest that spindles facilitate processing of relevant memory features during sleep and that this process boosts memory consolidation," says Staresina. "While it has been shown previously," he continues, "that targeted memory reactivation can boost memory consolidation during sleep, we now show that sleep spindles might represent the key underlying mechanism."
Cairney adds, "When you are awake you learn new things, but when you are asleep you refine them, making it easier to retrieve them and apply them correctly when you need them the most. This is important for how we learn but also for how we might help retain healthy brain functions."
Staresina suggests that this newly gained knowledge could lead to effective strategies for boosting memory while sleeping.
So, though learning things from scratch à la "Dexter's Lab" may take a while to become a reality, we can safely say that our brains continue to learn while we sleep, and that researchers just got a lot closer to understanding why this happens.
From: https://www.medicalnewstoday.com/articles/Mar/2018
A desomorfina, assim como a morfina e a heroína, é um derivado do ópio. Usada para fins medicinais na terapia da dor crônica e aguda de alta intensidade, a desomorfina produz fortes ações de insensibilidade à dor. A ingestão de doses elevadas da substância causa euforia, estados hipnóticos e dependência. A desomorfina é de 8 a 10 vezes mais potente que a morfina, tratando-se de um opiáceo sintético com estrutura quase idêntica à da heroína, mas muito mais barata.
Supondo que, a 25 °C, a desomorfina tenha um pKa de 9,69, a morfina tenha um pKa de 8,21 e a heroína tenha um pKa de 7,60, tem-se que a
TEXTO 3
Sinopse do filme Capitão América: Guerra Civil
Capitão América: Guerra Civil encontra Steve Rogers (Chris Evans) liderando o recém-formado time de Vingadores em seus esforços continuados para proteger a humanidade. Mas, depois que um novo incidente envolvendo os Vingadores resulta num dano colateral, a pressão política se levanta para instaurar um sistema de contagem liderado por um órgão governamental para supervisionar e dirigir a equipe.
O novo status quo divide os Vingadores, resultando em dois campos: um liderado por Steve Rogers e seu desejo de que os Vingadores permaneçam livres para defender a humanidade sem a interferência do governo; o outro seguindo a surpreendente decisão de Tony Stark (Robert Downey Jr.) em apoio à supervisão e contagem do governo.
Capitão América 3 tem direção dos irmãos Joe e Anthony Russo, produção de Kevin Feige e grande elenco formado por Scarlett Johansson (Viúva Negra), Sebastian Stan (Soldado Invernal), Anthony Mackie (Falcão), Emily Van Camp (Agente 13), Don Cheadle (Máquina de Combate), Jeremy Renner (Gavião Arqueiro), Chadwick Boseman (Pantera Negra), Paul Bettany (Visão), Elizabeth Olsen (Feiticeira Escarlate), Pail Rudd (Homem-Formiga), Frank Grillo (Ossos Cruzados), William Hurt (General Thunderbolt) e Daniel Brühl (Barão Zenom).
Disponível em: http://www.adorocinema.com/noticias/filmes/noticia118069/. Acesso em: 02.11.2018.
Leia o breve resumo do filme ‘Yesterday’, 2019, dirigido por Danny Boyle: