What evidence from the research supports the potential
application of the developed cancer vaccine strategy?
Read the sentence below:
"Mister Marvel was very sick and had a weak heart. He ___ have had a heart attack."
Choose the sentence with the correct modal verb to the sentence structure:
"Mister Marvel was very sick and had a weak heart. He ___ have had a heart attack."
Choose the sentence with the correct modal verb to the sentence structure:
A professora Ana tem uma urna com 23 bolinhas azuis e
2 bolinhas brancas e em todas as suas aulas pede que
cada aluno sorteie uma e os dois que tiram as bolinhas
brancas vão ajudá-la na organização da aula. Qual é a
probabilidade que o primeiro aluno a tirar uma bolinha
tem de ser um dos ajudantes da professora?
O texto seguinte servirá de base para responder à questão.
Ship carrying explosive fertiliser heads to UK waters
A Maltese-flagged cargo ship carrying thousands of tonnes of potentially explosive fertiliser is set to travel through UK waters.
Ruby, which was earlier accompanied by an escort tug, has reportedly been rejected by several countries due to its cargo.
The ship, which has 20,000 tonnes of ammonium nitrate on board, was previously damaged but deemed seaworthy by authorities in Norway.
HM Coastguard is in contact with the vessel, which according to ship tracking data, was in the North Sea off the Kent coast on Thursday morning.
The ship, owned by Maltese firm Ruby Enterprise, set off from the northern Russian port of Kandalaksha in July.
The national maritime emergency service said it will monitor the ship's progress as it heads towards and through UK waters.
Vessels are not required to ask permission to travel through UK territorial waters for legitimate purposes.
An escorting tug, Amber II, which had sailed with the boat from Norway, left the Ruby on Thursday morning and sailed east. Its current destination is listed as Rotterdam, in the Netherlands.
Though there is no suggestion of immediate danger from the cargo, the same chemical caused a devastating blast at a Beirut warehouse in 2020.
Ammonium nitrate is regularly transported around the world and used as fertiliser but is also used in explosives.
The ship is carrying seven times the amount of ammonium nitrate that caused the Beirut explosion.
Ruby's location on Thursday, according to Marine Traffic. Marine Traffic data suggested the ship was in the North Sea on Thursday.
Soon after departing Russia, the Ruby briefly ran aground after reportedly encountering a storm.
It then continued its journey around the Kola Peninsula and docked in Tromsø, Norway.
Norway's Maritime Authority told the BBC the vessel was inspected by DNV Group to ensure it met safety and environmental standards.
The group found damage to its hull, propeller and rudder, but the Ruby was still deemed "seaworthy".
As a precaution, DNV Group, and the Maltese flag registry, insisted that a tug escort the vessel for the remainder of its journey.
The ship was bound for Klaipeda, in Lithuania, according to ship tracking firm MarineTraffic.
But despite being deemed seaworthy, the ship was denied entry to Klaipeda. Algia Latakas, the port authority's chief executive, told the BBC that this was "because of its cargo".
Andrea Sella, professor of chemistry at University College London, said the cargo was not high risk, unless there was a fire on board.
"While I understand the caution of the authorities in Troms, I suspect that the chances of a similar disaster to Beirut are relatively modest," she said.
She added: "It would also be interesting to know what the nature of the repairs might be as clearly welding might significantly raise the potential fire risk."
Other reports suggested Sweden had imposed a ban as well, but Sweden's transport agency denies this.
"What the Swedish authorities did was to follow the matter in case we would have needed to act in some way," a spokesperson told the BBC.
In recent weeks, the Ruby travelled south along Norway's coast and through the North Sea.
The ship reportedly has had restricted manoeuvrability, though the BBC has been unable to confirm this.
On 25 September, it anchored about 15 miles (25km) north east of Margate, in Kent, near the Dover Strait - one of the world's busiest waterways.
The Maritime and Coastguard Agency (MCA) said the vessel is "currently securely anchored outside UK territorial waters waiting for appropriate conditions to refuel at sea before passing through the English Channel".
Refuelling at sea is a common practice and will take place in accordance with safety procedures and in favourable weather, said the MCA.
Its current destination is listed as Marsaxlokk, in Malta.
But Maltese authorities have told local media that the ship can only enter the country if it empties its cargo beforehand.
Marco Forgione, director general of the Chartered Institute of Export & International Trade, raised concerns about potential "environmental damage".
"Should the ammonium nitrate start to leak out of the ship and contaminate the sea... shipping through the channel would have to be diverted to avoid further shifting the pollution through its waters," he said.
He added that damage as a result of the potential scenario would be "immense" and cause "ongoing disruption".
The vessel has appropriate safety certificates approved by the vessel's flag state and is able to make its own way, said the MCA.
https://www.bbc.com/news/articles/c62g95721leo
Which statement best describes the condition of the Ruby when it was inspected in Norway?
Which sentence correctly uses the comparative form of
an adjective?
Software nativo no Windows para trabalhar com arquivos
de imagens. Marque a alternativa CORRETA para o
software descrito.
João é um novo aluno de LIBRAS e tem dificuldade em
compreender a estrutura gramatical da língua. Qual
estratégia o instrutor deve utilizar para facilitar o
aprendizado de João?
Considerando os classificadores na LIBRAS, qual seria a
forma correta de sinalizar "um grupo de pessoas
sentadas em uma mesa redonda"?
Stanford Medicine scientists transform cancer cells into weapons against cancer
March 1, 2023 - By Christopher Vaughan
(1º§) Some cities fight gangs with ex-members whoeducate kids and starve gangs of new recruits. Stanford Medicine researchers have done something similar with cancer — altering cancer cells so that they teach the body's immune system to fight the very cancer the cells came from.
(2º§) "This approach could open up an entirely new therapeutic approach to treating cancer," said Ravi Majeti, MD, PhD, a professor of hematology and the study's senior author. The research was published March 1 in Cancer Discovery. The lead author is Miles Linde, PhD, a former PhD student in immunology who is now at the Fred Hutchinson Cancer Institute in Seattle.
(3º§) Some of the most promising cancer treatments use the patient's own immune system to attack the cancer, often __ taking the brakes off immune responses to cancer or by teaching the immune system to recognize and attack the cancer more vigorously. T cells, part of the immune system that learns to identify and attack new pathogens such as viruses, can be trained to recognize specific cancer antigens, which are proteins that generate an immune response.
(4º§) For instance, in CAR T-cell therapy, T cells are taken from a patient, programmed to recognize a specific cancer antigen, then returned to the patient. But there are many cancer antigens, and physicians sometimes need to guess which ones will be most potent.
(5º§) A better approach would be to train T cells to recognize cancer via processes that more closely mimic the way things naturally occur in the body — like the way a vaccine teaches the immune system to recognize pathogens. T cells learn to recognize pathogens because special antigen presenting cells (APCs) gather pieces of the pathogen and show them to the T cells in a way that tells the T cells, "Here is what the pathogen looks like — go get it."
(6º§) Something similar in cancer would be for APCs to gather up the many antigens that characterize a cancer cell. That way, instead of T cells being programmed to attack one or a few antigens, they are trained to recognize many cancer antigens and are more likely to wage a multipronged attack on the cancer.
(7º§) Now that researchers have become adept at transforming one kind of cell into another, Majeti and his colleagues had a hunch that if they turned cancer cells into a type of APC called macrophages, they would be naturally adept at teaching T cells what to attack.
(8º§) "We hypothesized that maybe cancer cells reprogrammed into macrophage cells could stimulate T cells because those APCs carry all the antigens of the cancer cells they came from," said Majeti, who is also the RZ Cao Professor, assistant director of the Institute for Stem Cell Biology and Regenerative Medicine and director of the Ludwig Center for Cancer Stem Cell Research and Medicine.
(9º§) The study builds on prior research from the Majeti lab showing that cells taken from patients with a type of acute leukemia could be converted into non-leukemic macrophages with many of the properties of APCs.
(10º§) In the current study, the researchers programmed mouse leukemia cells so that some of them could be induced to transform themselves into APCs. When they tested their cancer vaccine strategy on the mouse immune system, the mice successfully cleared the cancer.
(11º§) "When we first saw the data showing clearance of the leukemia in the mice __ working immune systems, we were blown away," Majeti said. "We couldn't believe it worked as well as it did."
(12º§) Other experiments showed that the cells created from cancer cells were indeed acting as antigen-presenting cells that sensitized T cells to the cancer. "What's more, we showed that the immune system remembered what these cells taught them," Majeti said. "When we reintroduced cancer to these mice over 100 days after the initial tumor inoculation, they still had a strong immunological response that protected them."
(13º§) "We wondered, If this works with leukemias, will it also work with solid tumors?" Majeti said. The team tested the same approach using mouse fibrosarcoma, breast cancer, and bone cancer. "The transformation of cancer cells from solid tumors was not as efficient, but we still observed positive results," Majeti said. With all three cancers, the creation of tumor-derived APCs led to significantly improved survival.
(14º§) Lastly, the researchers returned to the original type of acute leukemia. When the human leukemia cell-derived APCs were exposed to human T cells from the same patient, they observed all the signs that would be expected if the APCs were indeed teaching the T cells how to attack the leukemia.
(15º§) "We showed that reprogrammed tumor cells could lead to a durable and systemic attack on the cancer in mice and a similar response with human patient immune cells," Majeti said. "In the future we might be able to take out tumor cells, transform them into APCs and give them back to patients as a therapeutic cancer vaccine."
(16º§) "Ultimately, we might be able to inject RNA into patients and transform enough cells to activate the immune system against cancer without having to take cells out first," Majeti said. "That's science fiction __ this point, but that's the direction we are interested in going."
(17º§) The work was supported by funding from the Ludwig Foundation for Cancer Research, the Emerson Collective Cancer Research Fund, the New York Stem Cell Foundation, the Stinehart-Reed Foundation, the Leukemia and Lymphoma Society, the J. Benjamin Eckenhoff Fund, the Blavatnik Family Fellowship, the Deutsche Forschungsgemainshaft, the Knut and Alice Wallenberg Foundation, the Stanford Human Biology Research Exploration Program, the National Institutes of Health (grant F31CA196029), the American Society of Hematology, the A.P. Giannini Foundation, and the Stanford Cancer Institute.
(adapted)
med.stanford.edu/news/all-news/2023/03/cancer-hematology.html
PROFESSOR INGLÊS - 1 8
Choose the alternative that correctly fills in the blanks of
paragraphs 03, 11 and 16.
Stanford Medicine scientists transform cancer cells into weapons against cancer
March 1, 2023 - By Christopher Vaughan
(1º§) Some cities fight gangs with ex-members whoeducate kids and starve gangs of new recruits. Stanford Medicine researchers have done something similar with cancer — altering cancer cells so that they teach the body's immune system to fight the very cancer the cells came from.
(2º§) "This approach could open up an entirely new therapeutic approach to treating cancer," said Ravi Majeti, MD, PhD, a professor of hematology and the study's senior author. The research was published March 1 in Cancer Discovery. The lead author is Miles Linde, PhD, a former PhD student in immunology who is now at the Fred Hutchinson Cancer Institute in Seattle.
(3º§) Some of the most promising cancer treatments use the patient's own immune system to attack the cancer, often __ taking the brakes off immune responses to cancer or by teaching the immune system to recognize and attack the cancer more vigorously. T cells, part of the immune system that learns to identify and attack new pathogens such as viruses, can be trained to recognize specific cancer antigens, which are proteins that generate an immune response.
(4º§) For instance, in CAR T-cell therapy, T cells are taken from a patient, programmed to recognize a specific cancer antigen, then returned to the patient. But there are many cancer antigens, and physicians sometimes need to guess which ones will be most potent.
(5º§) A better approach would be to train T cells to recognize cancer via processes that more closely mimic the way things naturally occur in the body — like the way a vaccine teaches the immune system to recognize pathogens. T cells learn to recognize pathogens because special antigen presenting cells (APCs) gather pieces of the pathogen and show them to the T cells in a way that tells the T cells, "Here is what the pathogen looks like — go get it."
(6º§) Something similar in cancer would be for APCs to gather up the many antigens that characterize a cancer cell. That way, instead of T cells being programmed to attack one or a few antigens, they are trained to recognize many cancer antigens and are more likely to wage a multipronged attack on the cancer.
(7º§) Now that researchers have become adept at transforming one kind of cell into another, Majeti and his colleagues had a hunch that if they turned cancer cells into a type of APC called macrophages, they would be naturally adept at teaching T cells what to attack.
(8º§) "We hypothesized that maybe cancer cells reprogrammed into macrophage cells could stimulate T cells because those APCs carry all the antigens of the cancer cells they came from," said Majeti, who is also the RZ Cao Professor, assistant director of the Institute for Stem Cell Biology and Regenerative Medicine and director of the Ludwig Center for Cancer Stem Cell Research and Medicine.
(9º§) The study builds on prior research from the Majeti lab showing that cells taken from patients with a type of acute leukemia could be converted into non-leukemic macrophages with many of the properties of APCs.
(10º§) In the current study, the researchers programmed mouse leukemia cells so that some of them could be induced to transform themselves into APCs. When they tested their cancer vaccine strategy on the mouse immune system, the mice successfully cleared the cancer.
(11º§) "When we first saw the data showing clearance of the leukemia in the mice __ working immune systems, we were blown away," Majeti said. "We couldn't believe it worked as well as it did."
(12º§) Other experiments showed that the cells created from cancer cells were indeed acting as antigen-presenting cells that sensitized T cells to the cancer. "What's more, we showed that the immune system remembered what these cells taught them," Majeti said. "When we reintroduced cancer to these mice over 100 days after the initial tumor inoculation, they still had a strong immunological response that protected them."
(13º§) "We wondered, If this works with leukemias, will it also work with solid tumors?" Majeti said. The team tested the same approach using mouse fibrosarcoma, breast cancer, and bone cancer. "The transformation of cancer cells from solid tumors was not as efficient, but we still observed positive results," Majeti said. With all three cancers, the creation of tumor-derived APCs led to significantly improved survival.
(14º§) Lastly, the researchers returned to the original type of acute leukemia. When the human leukemia cell-derived APCs were exposed to human T cells from the same patient, they observed all the signs that would be expected if the APCs were indeed teaching the T cells how to attack the leukemia.
(15º§) "We showed that reprogrammed tumor cells could lead to a durable and systemic attack on the cancer in mice and a similar response with human patient immune cells," Majeti said. "In the future we might be able to take out tumor cells, transform them into APCs and give them back to patients as a therapeutic cancer vaccine."
(16º§) "Ultimately, we might be able to inject RNA into patients and transform enough cells to activate the immune system against cancer without having to take cells out first," Majeti said. "That's science fiction __ this point, but that's the direction we are interested in going."
(17º§) The work was supported by funding from the Ludwig Foundation for Cancer Research, the Emerson Collective Cancer Research Fund, the New York Stem Cell Foundation, the Stinehart-Reed Foundation, the Leukemia and Lymphoma Society, the J. Benjamin Eckenhoff Fund, the Blavatnik Family Fellowship, the Deutsche Forschungsgemainshaft, the Knut and Alice Wallenberg Foundation, the Stanford Human Biology Research Exploration Program, the National Institutes of Health (grant F31CA196029), the American Society of Hematology, the A.P. Giannini Foundation, and the Stanford Cancer Institute.
(adapted)
med.stanford.edu/news/all-news/2023/03/cancer-hematology.html
PROFESSOR INGLÊS - 1 8
In the context of 8º§, what could be a synonym for
"hypothesized"?
De acordo com a Lei Brasileira de Inclusão, é obrigatória
a presença de intérpretes de Libras em quais situações?
Um funcionário de uma secretaria municipal precisa
definir as metas para os próximos meses, levando em
conta o orçamento disponível e as necessidades da
população. Acerca da função administrativa ele está
exercendo nesse caso, marque a alternativa CORRETA:
Teams e______são ferramentas de comunicação e
podem ser combinados para tornar o trabalho mais
dinâmico e organizado. Quando você cria um grupo no
Teams ele se torna um local de trabalho com acesso a
vários aplicativos do Office 365, incluindo o_____e seus
grupos. Marque uma alternativa CORRETA que
completa as lacunas.
No Windows um nome de um arquivo não pode conter
alguns caracteres como. Marque a alternativa CORRETA
que corresponde ao caractere que não pode conter no
nome de um arquivo.
Dentre as etapas a serem seguidas num procedimento de efetivação de matrícula, ordene o processo:
I.Solicitação de vagas para novos alunos.
II.Efetivação da matrícula na unidade escolar.
III.Reordenamento na rede de ensino.
IV.Manutenção do banco de dados nas unidades escolares. V.Permanência e/ou transferência dos alunos da unidade escolar.
Fonte: Governo do Estado de Goiás. Escrituração Escolar. Formação, em Serviço, dos Gestores da Rede Estadual de Ensino: Secretário Geral, 2010.
Assinale a alternativa com a sequência CORRETA.
Analise a eficácia da abordagem oralista, que proíbe o
uso da língua de sinais, em comparação com a
abordagem bilíngue, que utiliza a Libras como primeira
língua, no ensino da Língua Portuguesa para surdos.
LIBRAS : Começou a ser utilizada no Brasil na
década de 90, e de lá para cá, passou a ser
reconhecida como uma das línguas oficiais do Brasil
em 2002.
A língua brasileira de sinais é formada por todos os
elementos que dizem respeito à língua oral
preenchendo, assim, os requisitos para ser
considerado um instrumento linguístico de grande
poder de atuação, além de ser considerada uma
língua oficial aqui no Brasil e ser a segunda mais
utilizada, perdendo apenas para o português falado.
Para se comunicar através dessa língua, existe uma
técnica que ensina os sinais a partir de
combinações, movimentos, entre outros, que são
realizados no momento da comunicação.
(__) Oralismo : Tem como principal caraterística
desenvolver a fala do sujeito surdo, pois para os
defensores deste método, a fala seria considerada
indispensável para comunicação e desenvolvimento
integral das crianças com deficiência auditiva.
(__) Comunicação total : Quando se constatou que
os surdos educados por meio da metodologia
Oralista não conseguiriam se comunicar ou falar
como os ouvintes de maneira satisfatória e que,
mesmo com a imposição das práticas oralistas, as
pessoas surdas insistiam em se comunicar por meio
da língua de sinais, decidiu-se então que os surdos
poderiam utilizar toda e qualquer forma de comunicação. Surge, então, o método que ficou
conhecido como Comunicação Total.
(__) Bilinguismo : Esta forma de comunicação visa o
uso das duas línguas dentro do ambiente escolar,
sendo neste caso, a LIBRAS e a língua portuguesa
de forma escrita. Se tem notícia de que esta
metodologia Bilíngue é utilizada atualmente com
surdos em algumas instituições educacionais
brasileiras.
(__) Pedagogia Surda : Esta metodologia surge com
o fim de apresentar um novo caminho para a
educação do sujeito surdo. Surge com a finalidade
de mostrar um novo caminho para a educação do
surdo, pois ela é uma metodologia que atende de
uma forma satisfatória as especificidades do surdo,
de forma a considerar todos os aspectos culturais
deste sujeito.
(__) Braille : O código Braille é composto por uma
combinação de pontos dispostos em uma célula de
três linhas e duas colunas. Por meio da combinação
destes símbolos, o deficiente visual pode realizar a
leitura e a escrita de qualquer tipo de texto.
Considerando (V) verdadeiro e (F) falso, complete as
lacunas acima e assinale alternativa que apresenta a
ordem correta de preenchimento de cima para baixo.
É um documento oficial, geralmente publicado por
órgãos governamentais, instituições públicas ou
entidades privadas, que tem como objetivo divulgar
informações relevantes sobre um processo seletivo,
licitação, concurso, chamada pública ou qualquer outra
atividade que demande a participação de interessados.
Esse documento estabelece as regras, condições e
critérios para a participação, garantindo a transparência
e a igualdade de oportunidades entre os participantes.
Pautado no texto, qual documento o contexto descreve?
Assinale a alternativa CORRETA:
Assinale a alternativa CORRETA:
A ____________________ promove a transparência ao
tornar as informações acessíveis aos cidadãos,
funcionários e demais partes interessadas. Isso fortalece
a confiança na Administração Pública. São fontes
confiáveis de informação, contribuindo para a
credibilidade e reputação da instituição ou órgão
governamental. A clareza e a precisão são essenciais
para estabelecer e manter essa credibilidade. Muitas
vezes formaliza decisões, normas e procedimentos,
garantindo que todos os membros da organização
estejam cientes e cumpram as diretrizes estabelecidas.
Garante que as ações e decisões da Administração
Pública estejam alinhadas com a legislação e
regulamentos.
Diante do contexto apresentado, assinale a alternativa que corretamente completa a lacuna do texto:
Diante do contexto apresentado, assinale a alternativa que corretamente completa a lacuna do texto:
Também conhecido por browser, trata-se de um software
que oferece para você opções para utilizar os serviços
da internet. Marque a alternativa CORRETA que
corresponde a um navegador da Microsoft que foi
descontinuado recentemente.